This article analyzes colonial medical practices as secular theodicies that helped Shape social injustice in South Africa and suggests that European delineations of disease were integral to the country’s colonization. It starts by demarcating conceptions of Africa as the ‘diseased continent,’ arguing that this trope was informed by a dominant medical paradigm that localized threats to European health in Africa’s climate and topography. In the second section, I argue that the birth of bacteriology in the 1880s created new public health concerns that situated disease in extra-corporal spaces. In the race-conscious colonies, these public health spaces were inserted between European and African social bodies, presenting African pathology as a dominant threat to public health. In the final section, I argue that medical discourse in the interwar era increasingly focused upon African culture as the source of disease and enveloped Africans in medical discourses on the peculiarities of the African mind. The European medical cartography ofAfrica and Africans thus emerges as a strategy of distinction, which provided a precedent for racial segregation.‬